文档介绍：Postmortem Study of Validation of Low Signal
on Fat-Suppressed T1-Weighted ic Resonance
Imaging as Marker of Lipid Core in Middle Cerebral
Artery Atherosclerosis
Wen-Jie Yang, PhD; Xiang-Yan Chen, PhD; Hai-Lu Zhao, PhD; Chun-Bo Niu, MD;
Bing Zhang, MD, PhD; Yun Xu, MD, PhD; Ka-Sing Wong, MD; Ho-Keung Ng, MD
Background and Purpose—High signal on T1-weighted fat-suppressed images in middle cerebral artery plaques on ex
vivo ic resonance imaging was verified to be intraplaque hemorrhage histologically. However, the underlying
ponent of low signal on T1-weighted fat-suppressed images (LST1) has never been explored. Based on our
experience, we hypothesized that LST1 might indicate the presence of lipid core within intracranial plaques.
Downloaded from Methods— T ic resonance imaging was performed in the postmortem brains to scan the cross sections of bilateral
middle cerebral arteries. Then middle cerebral artery specimens were removed for histology processing. LST1 presence
was identified on ic resonance images, and lipid core areas were measured on the corresponding histology sections.
Results—Total 76 middle cerebral artery locations were included for analysis. LST1 showed a high specificity (%; 95%
confidence interval, %–%) but a low sensitivity (%; 95% confidence interval, %–%) for detecting
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