文档介绍：Chapter een
Analgesics
镇痛药
Pharmacology Department of Liaoning Medical University Liu Zhuo
Pain
Overview
an unpleasant sensory and emotional experience felt as a result of the brain's response to the damage, disease or injury;
subjective on the base of objective;
having specific central connection
somatic pain, visceral pain, neuralgia;
sharp pain, dull pain, angina, etc.
Examples of pain scales
Glutamate(rapid transmitter)
Regulation of pain
P substance(slow transmitter)
Conception of analgesics
drugs that act on specific receptors in S to reduce perception of pain.
opioid analgesics
narcotic analgesics
addictive analgesics
PART 2 Opioid receptors
G-protein-coupled family
阿片受体 Opioid receptors
Extracellular
Cytoplasmic
NH2
HOOC
、、, three major subtypes of opioid receptors
---- receptor is in dispute
The receptors : analgesia, euphoriant, respiratory depressant, physical dependence properties of the typical opioid receptor agonist, . morphine.
The receptors: control spinal analgesia, sedation and miosis.
The receptors: analgesic effects.