文档介绍：第38章抗骨质疏松的药物
Drugs Used for the Treatment of Osteoporosis
广东医学院吴铁
第38章抗骨质疏松的药物
Drugs Used for the Treatment of Osteoporosis
Key concepts:
Osteoporosis is a disease of bone monly occurs in elderly patients, and is characterized by the degeneration of bone superstructure, a decrease of bone strength, an increase of bone fragility and thus an increased risk of fracture
第38章抗骨质疏松的药物
Drugs Used for the Treatment of Osteoporosis
Key concepts:
Drugs available for the prevention and treatment of osteoporosis are catalogued into three types in terms of their actions on affecting calcification and bone turnover.
第38章抗骨质疏松的药物
Drugs Used for the Treatment of Osteoporosis
Key concepts:
The first group is antiresorptive agents that mainly decrease the rate of bone loss through inhibiting the activity of osteoclasts. This group includes bisphosphonates, calcitonin, estrogen and iprioavone.
第38章抗骨质疏松的药物
Drugs Used for the Treatment of Osteoporosis
Key concepts:
The second group consists of agents that mainly promote bone formation by stimulating the activity of osteoblasts. These drugs include fluoride, parathyroid hormone and androgens.
第38章抗骨质疏松的药物
Drugs Used for the Treatment of Osteoporosis
Key concepts:
The third group consists of agents that improve bone mineralization or slow bone resorption or stimulate new bone formation, and includes calcium and vitamin D and its metabolites.
骨质疏松症(osteoporosis)是老年人最常见的一种全身代谢性骨病,被认为是世界上发病率、死亡率最高及保健费用消耗最大的世纪性疾病。
在未来的60年内世界范围内的髋骨骨折人数将达到600万人,而髋骨骨折的患者在1年内将有12%~40%死于各种合并症,存活者中也有50%的人行动不便。
第一节骨质疏松的发病机制
原发性骨质疏松症是以全身骨量减少,骨组织超微结构退变为特征,骨强度降低,致使骨的脆性增加以及骨折危险性增加的一种全身性骨骼疾病。
骨质疏松症的定义
第一节骨质疏松的发病机制
第一类:原发性骨质疏松症
第二类:继发性骨质疏松症
第三类:特发性骨质疏松症
骨质疏松症的分类