文档介绍：补救性肝移植临床疗效的系统评价
王洪良董建辉蓝柳根秦科李美思李海滨李壮江孙煦勇
解放军第三〇三医院移植医学研究院广西移植医学重点实验室广西移植医学工程技术研究中心
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摘    要:
目的评价补救性肝移植(SLT) 治疗肝癌的疗效。方法计算机检索Pub Med、EMbase、Cochrane数据库、中国生物医学文献数据库、中国学术期刊(网络版) 、中国学术期刊数据库和中文科技期刊全文数据库。无语种限制, 检索日期截至2016年8月31日。收集公开发表的关于SLT与一期肝移植(PLT) 治疗肝癌的病例对照研究, 对纳入的文献进行资料提取和质量评价, 采用Revman 。结果纳入17项研究共9 335例患者, SLT和PLT术后1年生存率及1年无瘤生存率差异无统计学意义(RR=, 95%CI:, P=;RR=, 95%CI:, P=) , 但3、5年生存率及3、5年无瘤生存率差异有统计学意义(RR=, 95%CI:, P=;RR=, 95%CI:, P=;RR=, 95%CI:, P=;RR=, 95%CI:, P=) , PLT疗效优于SLT。结论 PLT术后远期疗效优于SLT。
关键词:
原发性肝癌; 补救性肝移植; 复发性肝细胞癌; 系统评价;
作者简介:孙煦勇, Email:sxywn@
收稿日期:2016-12-12
基金:国家自然科学基金(81670596)
Clinical effect of salvage liver transplantation in the treatment of recurrent hepatocellular carcinoma after hepatectomy: a systematic review
Wang Hongliang Dong Jianhui Lan Liugen Qin Ke Li Meisi Li Haibin Li Zhuangjiang Sun Xuyong
Institute of Transplant Medicine, 303 Hospital of People's Liberation Army, Guangxi Key Laboratory for Transplantation Medicine, Guangxi Transplantation Medicine Research Center of Engineering Technology;
Abstract:
Objective To evaluate the clinical efficacy of salvage liver transplantation (SLT) for hepatocellular carcinoma. Methods Information up to August 31 th 2016 was retrieved from Cochrane library, Pubmed, EMbase, CBM, CNKI, CSPD and VIP without linguistic constraints. Collected publications were all about case-control study of SLT or primary liver transplantation for hepatocellular carcinoma. All the included articles were performed with data extraction and quality assessment and then analyzed with Rev Man 5. 3. Results A total of 17 articles including 9 335 patients were was no statistic difference between SLT and PLT on 1-year survival rate, 1-year disease-free survival rate (RR = 0. 93, 95% CI: 0. 80-1. 08, P = 0. 36; RR = 0. 94