文档介绍：·326· 络病学基础与临床研究(7) 连花清瘟胶囊治疗病毒性感冒的系统评价孙彬何稳智中山大学公共卫生学院(510080,广州) 【摘要】目的评价连花清瘟胶囊(连翘、金银花、炙麻黄、炒苦杏仁、石膏、板蓝根、绵马贯众、鱼腥草、广藿香、大黄、红景天、薄荷脑、甘草)治疗病毒性感冒的临床疗效和安全性。方法收集资料和评价纳入文献质量,运用Meta分析对资料进行定量综合,评价不良反应,有6个随机临床对照研究纳入评价。结果 Meta分析结果显示:(1)对6项研究的临床疗效显效率合并效应量的检验:OR=,95%的置信区间为[,],Meta分析结果有统计学意义(P<);(2)对6项研究的退热率合并效应量的检验:OR=,95%CI为[,], (P<);(3)6项研究报道的不良反应例数:连花清瘟胶囊组675例中有14例胃肠不适,%;对照组527例中有19例,%;(4)在治疗前后对连花清瘟胶囊组患者血、尿、粪常规、肝肾功能、心肌酶和电解质的检验,均未发现异常变化。结论连花清瘟胶囊对病毒性感冒患者的治疗和改善有效安全。受纳入文献的质量限制,其疗效有待高质量的随机对照试验来评价。【关键词】连花清瘟胶囊;病毒性感冒;Meta分析;系统评价 rn-esystematic review ofLianhuaqingwen capsule on influenza virus SUN Sui- Health Collegeof Zhongshan University,Guangzhou 510080,China 【Abstract】Objective Toevaluate thethe clinicalefficacy and safetyofLianhuaqingwencapsules(forsythia,ho- neysuckle。sunburn ephedra,fried biaer almond,plaster,radix,cotton horse guanzhong,Houttuynia,patchouli,rhubarb, ,licorice)in thetreatment information was collected and thequality theincluded studiesWasevaluated,quantitative datasynthesis was analyzied byusing Metaanalysis,evaluated theadverse randomized controlled studies were bringed The results Meta analysis showed that:(1)The efficiency theclinicalefficacy the6studies bined and the was tested:OR=, 95%confidence interval[,],Metaanalysis resultswe