文档介绍：化疗引起的恶心呕吐
Chemotherapy induced nausea and vomiting(CINV)
Chemotherapy induced nausea and vomiting(CINV)
恶心和呕吐是因二天
第三天
第四天
Aprepitant
125mg
80mg
80mg
無
Dexamethasone
12mg口服
8mg口服
8mg口服
8mg口服
Ondansetron
32mg靜脈注射
無
無
無
Aprepitant trial Ⅰ
Phase Ⅲ
Cisplatin≥70mg/m2
Stand therapy group
Ondansetron+ Dexamethasone d1
Dexamethasone d2-4
Aprepitant group
Ondansetron+ Dexamethasone + Aprepitant d1
Dexamethasone + Aprepitant d2-3
Dexamethasone d4
Hesketh PJ,Grunberg SM,Gralla RJ et oral neurokinin-1 antagonist aprepitant for the prevention of chemotherapy-induced nausea and vomiting:A multinational,randomized,double-blind,placebo-controlled trial in patients receiving high-dose cisplatin-the Aprepitant Protocol 052 Study Clin Oncol 2003;21:4112-9.
Aprepitant trial Ⅰ
Complete response:
no emesis and rescue therapy
Aprepitant trial Ⅰ
P
Stand therapy group
Aprepitant group
d1-5
＜
%
%
Acute phase
＜
%
%
Delay phase
＜
%
%
Complete response
Hesketh PJ,Grunberg SM,Gralla RJ et oral neurokinin-1 antagonist aprepitant for the prevention of chemotherapy-induced nausea and vomiting:A multinational,randomized,double-blind,placebo-controlled trial in patients receiving high-dose cisplatin-the Aprepitant Protocol 052 Study Clin Oncol 2003;21:4112-9.
Aprepitant trial Ⅱ
A randomized,double blind,placebo controlled trial:
High dose cisplatin
Stand therapy group
Ondansetron 32mg iv+ Dexamethasone 20mg po d1
Dexamethasone 8mg bid po d2-4
Aprepitant group
Ondansetron 32mg iv+ Dexamethasone 12mg po + Aprepitant 125mg po d1
Dexamethasone 8mg po + Aprepitant 80mg po d2-3
Dexamethasone 8mg po d4
Poli-Bigelli S et of the neurokinin 1 receptor antagonist aprepitant to standard antiemetic therapy improves control of chemotherapy-induced nause and 2003;97:3090-8.
Aprepitant trial Ⅱ
Aprepita