文档介绍：胃癌患者microRNA与化疗敏感性的研究
尹晓菊骆玉霜(通迅作者) 赵君慧沈存芳范宝华
(青海大学附属医院肿瘤内科青海西宁 810000)
【摘要】 microRNA是一类内源性非编码单链RNA分子,其参与调控部分基因表达。某些microRNA不仅作为“癌基因”、“抑癌基因”参与胃癌的发生发展,还可调控胃癌的化疗敏感性。研究microRNA与胃癌化疗敏感性,为临床化疗开辟了新思路。本文就近年来的研究进展作一综述和分析。
【关键词】胃癌;microRNA;化疗敏感性
【中图分类号】R73 【文献标识码】A 【文章编号】2095-1752(2016)04-0005-02
Research of mirnas gastric cancer patients with chemotherapy sensitivity
Yin Xiaoju, Luo Yushaung (newsletter author), Zhao Junhui, Shen Cunfang, Fan Baohua.
Affiliated Hospital of Qinghai University. Qinghai Province, Xining 810000, China.
【Abstract】Mirnas is a kind of endogenous non-coding single-stranded RNA molecules that participate in the regulation of gene expression. Some mirnas not only as a "cancer genes", "tumor-suppressor gene", participate in the occurrence of gastric cancer development, can also be regulation of gastric cancer chemotherapy sensitivity. Study of mirnas and gastric cancer chemotherapy sensitivity, opened up a new way of thinking for clinical chemotherapy. This paper reviews and analyzes the research progress in recent years.
【Key words】 Gastric cancer; Micrornas; Chemotherapy sensitivity
多数胃癌患者确诊时已属中晚期,失去手术根治机会,通常5年生存率不超过20%,预后极差。全身化疗为这部分患者主要治疗措施。由于存在肿瘤细胞耐药,尤其是肿瘤多药耐药(Multidrug resistance,MDR),严重影响了化疗疗效
及预后。如何提高胃癌对化疗药物的敏感性,提高化疗疗效是目前临床关注的焦点。近年研究显示,microRNA可能增加或降低肿瘤化疗的敏感性。本文就近年来microRNA调节胃癌化疗药物的敏感性的研究进展作一综述。
microRNA简称miRNA,是一类长约18~25个