文档介绍：多西他赛联合卡培他滨治疗FOLFOX 方案失败晚期胃癌的临床观察
西安一四一医院 710000
【摘要】目的:观察多西他赛联合卡培他滨方案治疗FOLFOX方案(草酸铂+5-***尿嘧啶/亚叶酸钙)失败晚期胃癌的疗效和不良反应。方法 27例FOLFOX方案失败的晚期胃癌患者, 应用多西他赛联合卡培他滨方案治疗2~6个周期。观察疗效。结果27例均可评价, 有效率为37%, 其中完全缓解1例, 部分缓解9例(%), 稳定11例(%), 进展7例(%), 中位生存期10个月。不良反应主要为恶心呕吐、腹泻、骨髓抑制和肝功能损害, 但均为轻度。结论多西他赛联合卡培他滨方案方案治疗FOLFOX方案失败的晚期胃癌有一定疗效, 不良反应可耐受, 值得临床推广应用。
【关键词】胃癌;多西他赛;卡培他滨
Clinical observation of Docetaxel bination with
Capecitabine regimen in the treatment of gastric carcinoma with failed FOLFLX regimen
ZHANG Li-xia Xi 'an 141 Hospital
【Abstract】Objective to observe the curative effect and adverse reactions of Docetaxel bination with Capecitabine regimen in the treatment of advanced gastric carcinoma with failed FOLFLX regimen (oxaliplatin+5-fluorouracil/calcium folinate). Methods There were 27 patients with advanced gastric carcinoma received failed FOLFOX regimen, and they all received Docetaxel bination with Capecitabine regimen for treatment for 2~6 period. Curative effect was observed. Results All the 27 cases could be evaluated, and their effective rate was %. There were 1 case plete remission, 9 cases of partial remission (%), 11 stable cases (%), and 7 progressed cases (%). The median survival time was
10 months. The main adverse reactions included nausea and emesis, diarrhea, myelosuppression, and liver function damage all at mild stage. Conclusion Docetaxel bi