文档介绍：NP方案化疗联合放疗治疗晚期非小细胞肺癌临床疗效
【摘要】目的回顾分析NP方案联合适形放疗治疗晚期非小细胞肺癌的临床疗效和毒副作用。方法 32例Ⅲ期和Ⅳ期非小细胞肺癌患者,均行夹心序贯法NP方案化疗联合适形放疗。NP方案为诺维本25mg/m2,d1,d8;DDP25mg/m2,d1-3,21天为1周期。化疗两周期后行三维适形常规分割放疗,之后再化疗。放射源为直线加速器X线,15MV,照射剂量为36~66Gy。锁骨上区预防照射,8MeV电子线,20~30Gy。结果夹心序贯法化疗联合放疗总有效率(RR)%,其中1例达到完全缓解。ⅢA、ⅢB和Ⅳ期患者有效率(RR)%, %%。鳞癌、%、%。疾病控制率(DCR)%(29/32)。中位疾病进展时间(TTP)为178天(60~446天)。主要毒副反应为骨髓抑制、胃肠道反应、放射性肺炎和放射性食管炎,均可以通过相应措施予以纠正和缓解。结论 NP方案化疗联合放疗对晚期非小细胞肺癌有较好的近期疗效和疾病控制率,毒副反应能够被患者耐受。
【关键词】非小细胞肺癌;化疗;放疗
ABSTRACT: Objective To analyze retrospectively the clinical effects and side effects of bination of NP chemotherapy al radiotherapy in treating advanced stage nonsmall cell lung(NSCLC) cancer. Methods 32 patients of stage Ⅲ and Ⅳ nonsmall cell lung cancer otherapy and radiotherapy, follootherapy again. The NP regimen included Navelbine (25mg/m2, d1, d8) and DDP (25mg/m2, d13), repeated every 21 days. Conventional fractionation 3dimentional conformal radiotherapy ed using 15MV xrays after 2 cycles of chemotherapy, ore cycles of chemotherapy ed. Prophylactic supraclavicular irradiation o ous and adenocarnomal NSCLC achieved % and % RR respectively. The disease control rate (DCR) edium time to progression (TTP) arroonitis and radiation esophagitis, all of easurements. Conclusion The bination of NP chemotherapy al radiotherapy has good therapuntics effect and DCR in NSCLC p