文档介绍：生堡邀生堑堂塑鱼痤堂盘查忌旦筮丝鲞筮堋也』丛生堂堡坠:』翌翌垫荩簓尘:丝:盟··
细菌学
四种常用细菌感染指标的动物实验研究
谢尹晶段晋燕张洪瑞刘一凡唐红卫吴小利罗燕萍杨继勇王成彬
【摘要】目的监测全身感染性疾病小鼠模型血液中的相关炎症指标,探讨它们在鉴别诊断革兰
阴性菌和革兰阳性菌感染方面的价值。方法分别通过尾静脉注射大肠埃希菌和金黄色葡萄球菌建立
1 h10h12 d
小鼠,检测其血液白细胞计数 blood — proteinCRP)
素原,和白细胞介素琁。结果大肠埃希菌感染组和金黄色葡萄
WBC10h(19052)109L(21070)109L
诟腥竞飨陨撸直鹞±./,./;苍诟腥竞 h
(18246_+3314)pgml(5944_+930)pgmlIL-61h
为痬跣远哉兆楹徒鸹粕咸亚蚓腥咀榈腎骄陀诩觳庀孪蓿种指标的
叻治鱿允荆阶镮腞曲线下面积 under the curveAUC)
指标无差异。结论、蚉在感染早期即明显升高,且水平在大肠埃希菌和金黄色葡萄
球菌引发的感染中有显著差异。
【关键词】 C-6
Study model infectionli|g
JinyanZhangltongruiLiuYifanTangHongweiWuXiaoliLuo, ,
.’ LaboratoryChinesePLA General HospitalBeijingl00853China
Corresponding : .簑.
Abstract0bjective explore the possibility using circulating for
the diagnosis — and . bacterial mouse .
Methods Escherichia and through
establish the infeetion gram-negative and —.
Fotit including the white blood 珻— protein(CRP)pmcalcito
nin(PCT)and interleukin 6(IL-6)in blood samples 1361012hoursas 2 and
5 after 甊 WBC Escherichia and .
increased significantly hours after 畐..疞 and
.. CRP[(2581134)ngmland(2335599)rigm1]and
./ ±痬 all significantly upregulated 3 hours after ·
oculationLevels transiently increased Escherichia the point
l hours f(226342)pgmJ琤 below limit any other
control group and 甌 ROC indicated
the the significant differences between two .
.瓹 and PCT significantly increased early stage bacterial