复方山葛降脂胶囊的降脂作用研究.doc

文档介绍：复方山葛降脂胶囊的降脂作用研究
摘要:目的研究复方山葛降脂胶囊对高血脂模型大鼠的降脂作用。方法用高脂饲料喂养大白鼠建立大鼠高血脂模型,用复方山葛降脂胶囊低,中,高三个剂量药物溶液给大鼠灌胃给药。连续8天,观察并记录各组大鼠的行为及生活状况。用半自动分析生化仪测定高脂血症大鼠中总胆固醇(TC),甘油三酯(TG),高密度脂蛋白(HDL-C),低密度脂蛋白(LDL-C)的值等生化指标。结果复方山葛降脂胶囊能显著降低高脂血症大鼠TC,TG,LDL-C和升高HDL-C的水平。结论复方山葛降脂胶囊对高脂饮食诱导的高血脂模型大鼠具有明确的降脂作用。
关键词:山楂;葛根;何首乌;高血脂大鼠;降血脂
Lipid-decreasing effect research pound shan ge lipid lowering capsules
Abstract: abserve lipid-decreasing effect pound shan ge lipid lowering capsules on hyperlipidemia rats model. Methods After Rat models of high blood lipid level were induced by feeding with high-lipid feedstuff, the rats were administrated intragastrically with high does, median does and low does extraction pound shan ge lipid lowering capsules by eight days Observe and record the status of behavior and life of hyperlipidemia rat ,then the serum was obtained and the total cholesterol(TC), triglyceride(TG) ,lowd ensitylipoprotein -cholesterol (LDL-C)and high density -cholesterol(HDL-C) level and other biochemical parameters in serum were measured with semi-automatic biochemistry analyzer. pound shan ge lipid lowering capsules could reduces TC,TG,LDL-C level and increase HDL-C level significanty on hyperlipidemia rat. pound shan ge lipid lowering capsules shows notable antihyperlipidemia effect on hyperlipidmia rat model induced by high fat diet.
Keywords: Hawthorn,KudzuPolygonum,multiflorum,Plasma lipid,Lipid - decreasing
目录
摘要 I-II
1前言 1
2 实验材料 4
仪器和设备 4
实验试药 4
动物 5
3 实验方法 5
高脂饲料的制备 5
分组及建立模型 5
大鼠的给药方法 5
检测指标 6
统计学方法 6
4 结果与分析 6
对大鼠的体重和日常行为的影响 6
对大鼠血脂水平的影响 8
5 讨论 12
参考文献 13
综述 15
致谢 22
1前言
近年来,随着社会的发展和进步,人们生活水平和消费能力不断提高,高热量类食品摄入量显著增加,造成膳食结构不合理,营养不均衡,导致高血压、高血脂病等慢性非传染性疾病的患病率不断上升[1,2]。高脂血症是由于人体脂质代谢发生紊乱,血浆内脂质浓度超出正常范围的一种病症,是一种常见的且多发性代谢疾病,与糖尿病、肥胖、脂肪肝以及高血压、动脉粥样硬化等疾病的形成有密切联系。由于脂质多与血浆中蛋白结合,故又称作高脂蛋白血症。临床主要表现为血清总胆固醇(TC)、甘油三酯(TG)和低密度脂蛋白-胆固醇(LDL-C )水平过高或高密度脂蛋白-胆固醇(HDL-C)水平过低。而高脂血症的并发症发生也更加频繁,由于脂质代谢紊乱,血液中的胆固醇水平,血清甘油三脂水平升高,过多的脂质在血管壁的累积,导致血管内壁粥样硬化斑块的形成,血液流变