2011-基于大分子肿瘤靶向课件-@般若黑洞.ppt

文档介绍：【般若黑洞】出品
Northwestern Polytechnic University
基于大分子的
药物控释
肿瘤靶向
Polymeric
Tumor-Targeting
Drug Controlled Release
Drug Load
装载
定位
Targeting
Drug Release
释放
胶束
Micelles
树枝状聚合物
Dendrimers
Liposomes
微脂囊
聚合物-药物
偶联物
Polymer-drug
conjugates
Drug Load
装载
定位
主动
active
被动
passive
Targeting
配合基-受体
Ligand-receptor
EPR效应
EPR Effect
叶酸
cRGD
正常组织
癌变部位
Drug Release
释放
pH
温度
降解
磁场
UV
电场
内因
外因
PDEAEMA
PNIPAM
-s-s-
hydrazone bonds
多层
分子设计
Molecular Design
嵌段
分子量
端基
ATRP
RAFT
点击化学
超分子
星形
开环
Tumor-Targeting Peptide Conjugated pH-Responsive Micelles as a Potential Drug Carrier for Cancer Therapy
Xiang Lan Wu, Jong Ho Kim
Tumor-Targeting, pH-Responsive, and Stable Unimolecular Micelles as
Drug Nanocarriers for Targeted Cancer Therapy
Xiaoqiang Yang, Jamison J. Grailer, Srikanth Pilla
PEG-SS-PPS: Reduction-Sensitive Disulfide Block Copolymer
Vesicles for Intracellular Drug Delivery
Xiang Lan Wu, Jong Ho Kim