文档介绍：10/19/05 Gene Regulation (formerly Gene Prediction - 2)
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D Dobbs ISU - BCB 444/544X: Gene Regulation
Gene Prediction & Regulation
Mon - Overview & Gene structure review:
Eukaryotes vs prokaryotes
Wed - Regulatory regions:
Promoters & enhancers
- Predicting genes
Fri - Predicting genes
- Predicting regulatory regions
Next week: Predicting RNA structure (miRNAs, too)
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D Dobbs ISU - BCB 444/544X: Gene Regulation
Reading Assignment (for Wed)
Mount Bioinformatics
Chp 9 Gene Prediction & Regulation
pp 361-385 Predicting Promoters
Ck Errata: p/
* Brown Genomes 2 (NCBI textbooks online)
Sect 9 Overview: Assembly of Transcription plex
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Sect - DNA binding proteins, Transcription initiation
.gov/books/?rid=
* NOTE: Don’t worry about the details!!
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D Dobbs ISU - BCB 444/544X: Gene Regulation
Optional Reading
Reviews:
Zhang MQ (2002) Computational prediction of eukaryotic protein-coding genes. Nat Rev 3:698-709
:2103/nrg/journal/v3/n9/full/
Wasserman WW & Sandelin (2004) Applied bioinformatics for the identification of regulatory elements. Nat Rev 5:276-287
:2103/nrg/journal/v5/n4/full/
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D Dobbs ISU - BCB 444/544X: Gene Regulation
Review last lecture: Genes & Genomes (formerly Gene Prediction - 1)
Eukaryotes vs prokaryotes
Cells
anization
Gene structure
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D Dobbs ISU - BCB 444/544X: Gene Regulation
Eukaryotes vs Prokaryotes
Eukaryotic cells are characterized by membrane-partments, which are absent in prokaryotes.
“Typical” human & bacterial cells drawn to scale.
BIOS Scientific Publishers Ltd, 1999
Brown Fig
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D Dobbs ISU - BCB 444/544X: Gene Regulation
Comparison of Gene Structures
BIOS Scientific Publishers Ltd, 1999
Brown Fig
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D Dobbs ISU - BCB 444/544X: Gene Regulation
Summary: Genes & Genomes (formerly Gene Prediction - 1)
Genes in