文档介绍：缬沙坦对2型糖尿病肾病相关炎症因子的影响
:唐暎, 蒋晓红, 华飞, 董吉祥
【摘要】目的: 观察缬沙坦对2型糖尿病早期肾病相关炎症因子的影响及对糖尿病肾病的保护作用。方法: 2型糖尿病早期肾病患者60例,随机分为常规治疗组30例,缬沙坦组30例,全自动生化分析仪测定血糖、血脂、血肌酐(Scr)、C反应蛋白(CRP)等,干式化学法测定24小时尿蛋白,放免法测定尿白蛋白排泄率(UAER),ELISA法测定血清转化生长因子β1(TGFβ1)、白介素6(IL6)、肿瘤坏死因子α(TNFα)、白介素18(IL18)。结果: (1) 缬沙坦组治疗后ALB/Cr、24小时尿蛋白、UAER明显降低,而治疗前后血压无明显差异。(2) 缬沙坦组治疗后CRP、TGFβ1、IL6、IL18、TNFα等均显著降低。结论: 缬沙坦在降压作用之外还能减轻炎症反应,减少蛋白尿,延缓糖尿病肾病的发生、发展。
【关键词】缬沙坦; 糖尿病肾病; 炎症因子; 尿白蛋白排泄率
[Abstract] Objective: To study the influence of valsartan to correlated inflammatory cytokine in early stage of type 2 diabetic nephropathy and the protection to diabetic nephropathy. Methods: Sixty patients ly into t creatinine and C reactive protein(CRP) easured by automatic biochemistry analyzer. Teasured by drytype chemical method. Urinary albumin excretion rate (UAER) easured by radioimmunity method. Serum transforming groor necrosis factorα(TNFα)and interlukin18(IL18) easured by enzyme linked immunosorbent assay(ELISA) method. Results: (1) ALB/Cr, 24hour urine protein and UAER of the group CRP, TGFβ1, IL6, IL18 and TNFα of group ent of diabetic nephropathy by decreasing the level of correlated serum inflammatory cytokines and urine protein.
[Key matory cytokine; urinary albumin excretion rate
糖尿病肾病(diabetic nephropathy ,DN)是糖尿病常见的微血管并发症,是糖尿病患者致残、致死的重要原因之一。近年来,慢性炎症与糖尿病肾病的关系越来越受到重视。我们测定了DN患者缬沙坦治疗前后血清炎症因子白介素6(IL6)、转化生长因子β1(