Integrated Drug Discovery Technologies.pdf

文档介绍：Integrated Drug
Discovery
Technologies
edited by
Houng-yau Mei
Rubicon Genomics, Inc.
Ann Arbor, Michigan
Anthony W. Czarnik
Sensors for Medicine and Science, Inc.
Germantown, Maryland
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Preface
We scientists in the drug discovery business are not so different from alchemists
of old: “Convert this lead into gold and I shall share my wealth with you.” Or
perhaps, “Convert this lead into gold or else!” You’ve no doubt felt motivation
from both the carrot and the stick during your career, but it probably sounded more
like this: “If you can make a better COX-2 inhibitor, pany’s stock will
triple!” Or, “If we don’t fill our pipeline quickly, someone is going to buy us!”
Whether then or now, the risk/reward ratio is literally a step function, not a con-
tinuum, dependent on a scientist plishing a mission his analytical con-
science cannot guarantee.
Now, as in earlier times, we try anything that makes sense in the discovery
process. Becaus