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补肾健脾法治疗轻度认知功能障碍的临床研究.docx

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补肾健脾法治疗轻度认知功能障碍的临床研究.docx

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补肾健脾法治疗轻度认知功能障碍的临床研究.docx

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目的:观察自拟方益源复智饮治疗轻度认知功能障碍的临床疗效,并从中医学角
度探讨其病因病机。
方法:参考目前国际公认的轻度认知功能障碍诊断标准,将符合纳入标准的轻度
认知功能障碍患者62例,采用随机对照分组,分为治疗组(30例)和对照组(32例)。
治疗照组服用“益源复智饮”;对照组服用长春***缓释胶囊(奥勃兰)。3个月为一个疗
程。观察两组患者用药前后简易智能状态检查量表(MMSE)积分,蒙特利尔认知功
能量表(MoCA)积分,中医临床症状积分的变化情况。
结果:治疗组与对照组治疗前后在 MMSE 量表积分、MoCA 量表积分及中医临
床症状积分差异有统计学意义(P<);两组治疗前后差值比较在 MMSE 量表分
值,MoCA 量表分值上无统计学意义(P>),但中医临床症状积分差值比较,有
统计学意义(P<);依据中医临床症状疗效评定标准,治疗组与对照组经统计学
检验,两组中医临床症状疗效差异具有统计学意义(P<)。
结论:中药汤剂“益源复智饮”能改善 MCI 患者神经心理学量表积分,中医临
床症状,对延缓轻度认知功能障碍的进展有一定的改善作用。
关键词

轻度认知功能障碍

益源复智饮脾肾两虚
Clinical Study on Treatment of Mild Cognitive Impairment by Bushenjianpi
Specialyt: Internal Medicine of TCM-Clinical study on Nerve System Disease
Author: Li dingding
Tutor: Prof. Sun lijun
Abstract
Objective:To investigate the clinical efficacy of yiyuanfuzhi self-treatment to mild
cognitive impairment,and from the traditional medicine point of view research its etiology
of disease.
Methods:According to the internationlly recognized diagnostic criterion of mild
cognitive impairment, selected 62 cases of patients with MCI, randomized grouping,
divided into treatment group (n=30) and control group (n=32).30 cases in treated group
take Yiyuanfuzhi self-treatment ; 32 cases in control group take Brovincamine. Patients
will be observed before and after the scale mini-mental state examination(MMSE),The
Montreal Cognitive Assessment ( MoCA ) , the symptoms of traditional chinese
medicine(TCM) after 3months course of treatment。
Results:In the treatment groupand thecontrol group before and after treatment in
MMSE scores,MoCA scores,the scores of symptoms of TCM on the difference

between
statistical significance(p<);Comparsion of the two group before and after treatment in
MMSE scores,MoCA scores,the difference Was not statistically significant by statistical
tests(P> ) , but in Chinese medicine syndromes integration on the margin of
compariso, there are statistically significant(P<); Syndrome basis