文档介绍:该【中科院细胞与分子免疫学课程chapter10-课件 】是由【rongfunian】上传分享,文档一共【29】页,该文档可以免费在线阅读,需要了解更多关于【中科院细胞与分子免疫学课程chapter10-课件 】的内容,可以使用淘豆网的站内搜索功能,选择自己适合的文档,以下文字是截取该文章内的部分文字,如需要获得完整电子版,请下载此文档到您的设备,方便您编辑和打印。B细胞激活所需第二信号:C3d,CR2-CD19-C81T依赖抗原是怎样使B细胞产生各种各样抗体的:T、B细胞被抗原激活激活的T、B细胞相互迁移,发生接触。B细胞作为抗原递承细胞呈递抗原给T细胞。T细胞表面表达的CD40L,B细胞表面表达CD40。CD40L与CD40相互作用。T细胞分泌的细胞因子刺激B细胞B细胞分化为可产生抗体的细胞:上堂课回顾:发生在mRNA水平上的编辑:抗体膜型向分泌型转化发生在DNA水平上的重组:发生重链的转换,受不同细胞因子的刺激产生不同的抗体,IL-4:IgE;IFN-g:IgG晚期事件:亲和力发生改变产生记忆性细胞不依赖T细胞抗原产生抗体早期事件:Chapter10ImmunologicToleranceWhatisimmunologictolerance?,oleranceexperiment:–tolerancecanbedividedintotwotypes:Centraltolerance:Site:ansImmuneresponse:immatureself-:Site:inperipheralsitesImmuneresponse:matureself-–tolerancecanbedividedintotwotypes:EliminatemanyofthepotentiallymostdangerouslymphocytesUnresponsivenesstoselfantigensthatareexpressedinperipheraltissuesTlymphocyteToleranceCentralToleranceinTcellTwomainfactorsthatdeterminewhetheraparticularselfantigenwillinitiatethecentraltoleranceofTcells:TheconcentrationofthatantigeninthethymusTheaffinityofthethymocyteTCRInadditional:AIREgene:ene,:APS,:Whatsignaltriggersthecelltodieinresponsetohighaffinityoftheantigen?1)RoleofB7costimulatorsinTcellactivationandanergySeveralexperimentalsystemsillustratedtheanergyrelatedwithcostimulator.