文档介绍：Increased arterial stiffness may also explain impaired baroreceptor压力感受器 function in the elderly,[36] completing完成 the
Vicious恶性循环 circle of episodic偶发的 hypotension, impaired cerebrovascular autoregulation脑血管自动调节, and silent strokes.
36. Karemaker JM, Wieling W, Dunning AJ. Aging and the baroreflex. In: Amery A, Staessen J, eds.
Hypertension in the Elderly. Amsterdam, herlands: Elsevier Science Publishers BV; 1989:24 -38.
Atherothrombosis and Arterial Stiffness
The pathogenesis of atheroma动脉粥样化 formation形成 and the contribution of hypertension to it are poorly understood.[1] mon denominator命名 appears to be age- and hypertension-related stiffening of conduit管道 arteries, but the way in which increased stiffness leads to endothelial内皮的 damage and atheroma formation动脉粥样硬化形成 is not clear. In the Framingham cohort一群, systolic收缩 blood pressure, a marker of large artery distensibility扩大性, was more closely linked, in a positive fashion, to the occurrence发生 of atherothrombotic strokes than was diastolic舒张 blood pressure.[1] 1. Phillips SJ, Whisnant JP. Hypertension and stroke. In: Laragh JH, Brenner BM, eds. Hypertension,
Pathophysiology, Diagnosis and Management. 2nd Edition. New York, NY: Raven Press, Ltd.; 1995:465-
478.
However, the association between arterial stiffness and atheroma formation is not a strong one. Nor is hypertension高血压 a major
contributor to atheroma forma