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注射用喜炎平药效学研究
第11卷第7期 2009 年 7 月
辽宁中医药大学学报
JOURNAL OF LIAONING UNIVERSITY OF TCM
Vol. 11 No. 7 Jul .,2009
注射用喜炎平药效学研究
余洋1,丛艳2,权晓丹2,魏晶1
(,辽宁沈阳 110023;黑龙江哈尔滨 150090),摘要:目的:研究注射用喜炎平的药理作用。方法:进行了体内抗菌试验,解热试验,抗炎试验及止咳试
验。结果:注射用喜炎平对金黄色葡萄球菌、肺炎链球菌感染小鼠有明显的保护作用,、;有明显的解热、抗炎作用;对枸橼酸致豚鼠咳嗽次数有明显抑制作用。结论:注射用喜炎平具有清热解毒,抗菌消炎,止咳的药理作用。
关键词:注射用喜炎平;药效学;清热解毒;抗菌消炎;止咳
(2009)07- 中图分类号: 文献标识码:A 文章编号:1673-842X 0198- 03Pharmacodynamics Studies of XiYanPing for Injection
CONG Yan2,QUAN Xiao-dan2,WEI Jing1YU Yang1,
( Provincial Institute Control of Food and Drug Products,Shenyang
110023,Liaoning,China; Three Yang Pu Medicine Science and
pany Limited,Harbin 150090,Heilongjiang,China)
Objective:To investigate the pharmacologic action of XiYanPing for :We Abstract:
Results:s- the antibacterial in vivo test, fever-relieving test, anti-inflammatory test and antitussive test.
XiYanPing for injection had remarkable effect on mice infected by SA and SP,and the ED50s of it given by were , respectively;It had significantly anti-inflammatory effects and fever-relieving for injection had obvious antitussive effect guinea-pig cough induced by citric acid,becouse it can reduced the frequence of :XiYanPing for injection has remarkable effects of clearing heat and toxic,antibacterial and anti-inflammation, antitussive.
Key words:XiYanPing injection;Pharmacodynamics;clearing heat and toxic;antibacterial and anti-inflammatory;antitussive
注射用喜炎平是一种新型中药制剂,是从蕨类
植物穿心莲中提取制成水溶性穿心莲总内酯磺化物,具有清热解毒,抗菌消炎,止咳的药理作用。本
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文研究了注射用喜炎平静脉注射给药对金黄色葡萄球菌、肺炎链球菌感染小鼠的保护作用试验;对内***所致家兔发热的解热作用试验;对醋酸所致的小鼠腹腔毛细血管通透性增高的影响试验;对枸橼酸-,为其进一步临床研究提供实验依据。
1 实验材料
受试药物注射用喜炎平,规格:125mg,批号:
SYXK(辽)2003-0024。
实验仪器电子天平(H51型);电子秤(T1000型);紫外分光光度计(UV-2450型);低温高速离心机(SIGMA-2K15型);离心机(80-1)