文档介绍：目
录
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摘
要···················································································2
ABSTRACT ············································································4
前
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研究方法··············································································7
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讨论················································································ 20
参考文献············································································ 28
综
致
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谢················································································· 45
华中科技大学硕士学位论文
缩略词表
缩略词
CSF
VDRL
RPR
TRUST
TPPA
FTA-ABS
HIV
NK
CT
MRI
MRA
CTA
DSA
LDH
VEP
1
中文全称
脑脊液
性病研究实验室实验
快速血浆反应素实验
甲苯胺红不加热血清试验
梅毒螺旋体明胶凝聚实验
荧光密螺旋体抗体吸附实验
人类免疫缺陷病毒
自然杀伤细胞
计算机断层扫描
磁共振
磁共振血管成像
CT 血管成像
数字减影血管造影
乳酸脱氢酶
视觉诱发电位
华中科技大学硕士学位论文
神经梅毒的临床特征及高危因素分析
华中科技大学同济医学院附属同济医院神经内科
硕士研究生:姜群群
指导教师:唐荣华教授
摘
要
目的:分析神经梅毒患者的临床特征,以提高对神经梅毒的认识,并探讨神经梅毒发
生的高危因素。
方法:收集我院 2004 年 1 月至 2014 年 1 月间出院诊断为神经梅毒的 63 例患者的临
床资料,运用回顾性分析的方法分析神经梅毒患者的临床特征;同时收集 57 例无中
枢神经系统感染的梅毒患者的临床资料作为普通梅毒组,通过对比分析无症状神经梅
毒患者与普通梅毒患者的临床资料探讨神经梅毒发生的高危因素,对比分析症状性神
经梅毒患者与无症状神经梅毒患者资料探讨症状性神经梅毒发生高危因素。
结果:1. 63 例神经梅毒患者中男性 44 例,女性 19 例,平均年龄(±)岁。
18 例,脑脊膜梅毒 10 例,脑膜血管梅毒 14 例,脊髓痨 12 例,麻
痹性痴呆 8 例,梅毒树胶样肿 1 例。,临床表现多种
多样,无明显特异性,影像学、电生理检查结果与病变部位有关。
组与普通梅毒组血清 RPR 滴度比较 p<,差异有统计学意义,而性别、年龄、驱
梅治疗史、外周血 T 细胞数及 NK 细胞数比较差异均无统计学意义。6、症状性神经
梅毒组与无症状神经梅毒组比较年龄及驱梅治疗史两项 p<,差异有统计学意义,
性别、血清 RPR 滴度、脑脊液细胞数、脑脊液蛋白水平比较均 p>,差异无统计
学意义。
结论:;无症状神经梅毒为最常见类型,其次为脑膜血管
梅毒,而脊髓痨、麻痹性痴呆及脑脊膜梅毒相对少见,梅毒性树胶样肿少见;多慢性
或亚急性起病;临床表现多种多样,缺乏特异性,早发型痴呆、精神障碍、原因不明
的颅内感染、脊