文档介绍：Chin J Clin Pharmacol 1127 Vol畅30 No畅12 December 2014(Serial No畅182)头孢哌***/舒巴坦联合美罗培南对鲍曼不动杆菌体外抗菌作用研究In vitro efficacy of cefperazone -sulbactam and bination obacter baumannii收稿日期:2014 -02 -11修回日期:2014 -09 -15基金项目:江苏省实验诊断学重点实验室基金资助项目( XK201114 )作者简介:夏文颖(1986 - ),女,硕士研究生,主要从事感染与肿瘤的诊断研究通信作者:梅亚宁,主任技师Tel: (025)68136287E -mail:myn303@夏文颖, 梅亚宁, 顾兵,刘根焰(南京医科大学第一附属医院检验学部, 南京 210029)XIA Wen -ying, MEI Ya -ning,GU Bing, LIU Gen -yan( Department of Laboratory Medicine,The First Affiliated Hospital of NanjingMedical University, Nanjing 210029,China)摘要:目的观察头孢哌***/舒巴坦与美罗培南联合时对35 株临床分离的美罗培南耐药的鲍曼不动杆菌的体外抗菌作用。方法采用微量肉汤稀释法及联合药敏棋盘法,对35 株鲍曼不动杆菌进行头孢哌***/舒巴坦和美罗培南的体外联合药物敏感性测定,通过计算部分抑菌指数(FIC)来判断头孢哌***/舒巴坦与美罗培南的联合效应。结果头孢哌***/舒巴坦与美罗培南联用对35 株美罗培南耐药的鲍曼不动杆菌的最低抑菌浓度(MIC)较单用均明显下降(P <0畅01);用联合药敏棋盘法检测协同作用为54畅3%(19/35),部分协同作用为 34畅3%(12/35),相加作用为 5畅7%(2/35),无关作用为5畅7%(2/35),无拮抗作用。结论头孢哌***/舒巴坦联合美罗培南对于美罗培南耐药的鲍曼不动杆菌主要表现为协同和部分协同作用。关键词:鲍曼不动杆菌;头孢哌***/舒巴坦;美罗培南;棋盘法DOI:10畅13699 /ki畅1001 -6821畅2014畅12畅016中图分类号:R978畅1;R969畅3 文献标志码: A文章编号:1001 -6821(2014)12 -1127 -03Abstract: Objective To evaluate the synergy effect of cefperazone -sulbactam and bination against 35 meropenem -obacter baumannii isolated from clinical specimens in vitro畅Methods The synergy effect of cefperazone -sulbactam and bination was evaluated through microdilution checkerboard method a -gainst 35 meropenem resistant A畅baumannii were isolated from inpa- inhibit