文档介绍：The research progress of relationship between PAPP-A and coronary heart disease
Abstract
Background: Coronary heart disease(CHD) has seriously harmed the human health. Recent researches show that inflammatory reaction plays a important role in the forming and development of atherosclerosis , with various inflammatory factors and macrophage. One of the inflammatory factor being studied hotly is PAPP-A(pregnancy-associated plasma protein-A). It is founded that PAPP-A has a significant role in VP(vulnerable plaque)forming and developing, and it is VP that
directly induces ACS(acute coronary syndrome). So there are a lot of studies on the
relationship between PAPP-A and ACS.
Objective: Through studies on the structure and function of PAPP-A and IGF axis, we discuss the relationship between PAPP-A and atherosclerosis, and make further
clinical researches on PAPP-A application value in diagnosis,therapy and prognosis
evaluation of CHD.
Methods: Retrieve the literatures and summarize the progress in recent years relating to the structure and function of PAPP-A, the relationship between the level of PAPP-A and vulnerable plague and the relationship between the level of PAPP-A and
CHD in Wanfang ,Weipu and Pubmed database.
Results: PAPP-A is one member of metalloproteinase family, and can directly erode the plaque, inducing more thin-cap fibroatheromas and plaque ruptures; at the other side, PAPP-A enhances inflammatory reaction through IGF axis and indirectly decrease plaque stability. PAPP-A is valuable in prediciting major adverse cardiac
events、classifying risk of CHD and predicting the risk of no-reflow after it is
founded that PAPP-A s、CD40L and CRP participate formation of VP together.
Conclusion: PAPP-A has a significant role in atherosclerosis forming and developing, especially in VP. PAPP-A has some certain clinical value in diagnosis,
therapy and prognosis evaluation of CHD.
【Keywords】:PAPP-A, Vulnerable plaque, Coronary heart disease
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