文档介绍：PSEUDORABIES
Control and Eradication
伪狂犬病的控制和清除
朱稳森
美国谷物协会
广州
Pseudorabies 伪狂犬病
PRV 伪狂犬病病毒
Aujeskys Disease (AD) 奥叶斯基病
Infectious Bulbar Paralysis 感染性延髓麻痹
Historical Records report disease in Cattle in early 1800s
早在1800年有报道该病发生于牛
All species of mammals susceptible. 哺乳动物易感
Cats, Dogs, Sheep, Cattle, Horses, Rats, Monkeys.
Man is resistant. Rare reports in Humans (Skin rash).
人有抵抗性,人感染的报道很少见(皮疹)
PRV was often confused with swine fever.
常与猪瘟相混
急性:
流产,木乃伊,死胎,不孕
腹泻,中枢神经症状
High mortality in small pigs 仔猪高死亡率
Pre-wean can be almost 100% 断奶前几乎100%
5 - 9 weeks less than 10% 5-9周龄低于10%
Less than 2% in older pigs 稍大猪低于2%
Coughing, sneezing 咳嗽,喷嚏
Skin lesions/Itching (mon) 皮肤病变/痒(不多见)
Varying pathogenicity, sometimes acute form not seen
病毒的致病性不同,有时未见急性型
慢性:
Pneumonia in Grow-finish 生长肥育阶段肺炎
Immunity from sow lasts for
up to 15 weeks, protective 6 to 12 weeks
母体免疫力可持续到 15 周龄,但保护性只到 6-12 周龄
Immunosuppression, Secondary Infection 免疫抑制,继发感染
APP, Strep, Mycoplasma Interactions
Sow herd fairly stable, G/F is virus factory
母猪群很稳定,生长肥育猪产生病毒
Immunity can be cyclic in sow herd 母猪群免疫力可循环
Pseudorabies Spread 伪狂犬病的传播
Infected Pigs - 病猪
Lifetime Latent infection 潜伏感染
Virus Shedding when stressed
应激状态下产生病毒
Fomites 污染物
Trucks, Boots, Premises
卡车,靴子,环境
Aerosol 空气传播
Spreads 3 km very easily
很容易就能传播 3 公里
Circle/Area ination Essential
环形/区域免疫是必需的
PRV - Route of Infection 感染途径
Intranasal/oral route 鼻腔/口腔途径
Nasal Epithelial cells 鼻腔上皮细胞
Nerve Cells - - -> up nerves S
神经细胞--向上至中枢神经系统
Tonsil 扁桃体
Respiratory Tract 呼吸道
Lymphoid Tissues 淋巴组织
Semen/Uterine route possible
可能的精液/子宫途径
After Infection: 感染后
The Pig sheds virus for 10 to 14 days.
10-14天期间产生病毒
Virus es Latent in Nerve Tissue.
病毒在神经组织潜伏
Pig is infected for its Lifetime.
终生感染
Periodic recrudescence occurs.
周期性复发
Latent Infection is detectable by PCR.
PCR技术可检测潜伏感染
Gross Lesions 总体病变
Sometimes No Gross Lesions are visible
有时见不到总体病变
Multiple White Foci on Liver & Spleen