文档介绍：Advanced Drug Delivery Reviews 64 (2012) 557–570
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Advanced Drug Delivery Reviews
journal homepage: ate/addr
Oral drug delivery with polymeric nanoparticles: The gastrointestinal
mucus barriers☆
Laura M. Ensign a,b,⁎, Richard Cone a,f, Justin Hanes a,b,c,d,e,⁎⁎
a Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 N. Broadway, Baltimore, MD 21231, USA
b Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA
c Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
d Department of Oncology, The Sidney prehensive Cancer Center, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA
e Center for Cancer Nanotechnology Excellence, Institute for NanoBioTechnology, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA
f Department of Biophysics, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA
article info abstract
Article history: Oral delivery is the mon method for drug administration. However, poor solubility, stability, and
Received 16 July 2011 bioavailability of many drugs make achieving therapeutic levels via the gastrointestinal (GI) tract challeng-
Accepted 14 December 2011 ing. Drug delivery must e numerous hurdles, including the acidic gastric environment and the con-
Available online 24 December 2011
tinuous secretion of mucus that protects the GI tract. Nanoparticle drug carriers that can shield drugs from
degradation and deliver them to intended sites within the GI tract may enable more efﬁcient and sustained
Keywords: ﬁ
Oral delivery drug delivery. However, the rapid secretion and shedding of GI tract mucus can signi cantly limit the effec-
ﬁ
Mucus barrier tiveness of nanoparticle drug delivery systems. Many