文档介绍：The allogeneic transplant has the advantage over the autologous transplant
The graft does not contain tumor cells and the potential for a graft versus myeloma (GvM) effect
Bone marrow transplantation in three patients with multiple myeloma
Gahrton G, Ringdén O, Lönnqvist B, Lindquist R, Ljungman P.
Acta Med Scand 1986;219(5):523-7.
瑞典卡罗林斯卡医学院 1983
Myeloablative conditioning
Three patients with multiple myeloma received bone marrow grafts from HLA-identical sibling donors
One of the patients, with IgA kappa myeloma, refractory to alkeran-prednisone therapy, is well and still without sign of disease 26 months post transplantation
A second patient with Bence-Jones kappa myeloma is well, and skeletal pain and Bence-Jones proteinuria has disappeared 2 months after transplantation.
A third patient with IgG-lambda myeloma died of effusive pericarditis shortly after transplantation.
Acta Med Scand 1986;219(5):523-7
Conclusion
Bone marrow transplantation may be indicated in a selective group of patients with multiple myeloma
Acta Med Scand 1986;219(5):523-7
Out of 690 ic matched sibling donor transplants for MM
344 were performed during the period 1983-93(all with BM ) [group 1]
356 during 1994-98 (223 with BM group 2 and 133 with PB group 3)
the median age at transplantation of patients in group 1 was 43 years (range 21-62)
In group 2 ,44 years (range 18_57) and in group 3, 46 years (range 25_60)
TBI+CY tended to be monly used in group 1(37%) and 2 (39%) than in group 3 (27%)
Melphalan containing regimes tended to be morely used in group 3
Melphalan or Busulphan + CY rarely
Conditiong regime
Engraftment