文档介绍：应用化工技术毕业论文2_4_4-三***-2-羟基二苯醚的制法

2013年6月10日
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摘要:2,4,42三***.2’.羟基二苯醚()是市场畅销的一种杀菌剂。

关键词:2,4,4-三***.,杀菌剂,醚化,硝基还原,重氮化,水解,提纯

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Abstract:2,4,4。trichloro一2’一hyaroxydiphenylether(HD一244)is one of the most well—marked germicide and germ three synthesis technologies of HD一244 are introduced pared,The synthesis metIlod from 2,4一dichlomitrobenzen is focally studied,this synthesis technology include forming of salt、etherification、nitro reduction、diazotization、hydrolysis five effects of processing conditions on the product recovery and quality are researched,meantime, purlfy method of final synthesis product is results show that recovery of forming of salt and etherification、nitro
reduction、diazotization and hydFolysis is respectively %、%and %.and total recovery of HD一244 according to 2,4一dichlorbenzophenol is over 30%,relative content of product is all over %by HPLC at the different analysis wavelengths 210nm、235nm and 254nm,product es up to criterion of 2000
pharmacopeia(USP)and 2000 Ciba。and molecular structure of the product is determinated by IR and MS.

Keywords:2-4,4、trichloro-2 7一hydFOXydiphenylether,germicide, etherification,reduction,dizotization hydrolysis,pufffy

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前言
2,4,4’-三***-2-羟基二苯醚,也称5-***-2,4-二***苯氧基苯酚,国外商品名为Triclosan,Irgasan DP 300,Zileasan uw或Cloxifenol,,是二十世纪八十年代