文档介绍：770 Chem. Rev. 2008, 108, 770−813
Combinatorial and High-Throughput Development of Sensing Materials: The
First 10 Years
Radislav A. Potyrailo*,† and Vladimir M. Mirsky‡
Chemical and Biological Sensing Laboratory, Materials Analysis and Chemical Sciences, General Electric Global Research,
Niskayuna, New York 12309, and Institute of Analytical Chemistry, Chemo- and Biosensors, University of Regensburg, 93040 Regensburg, Germany
Received July 30, 2007
Contents a chemical or biological sensor is an analytical device that
utilizes a chemically or biologically responsive sensing layer
1. Introduction 770 to recognize a change in a single or multiple chemical or
. Requirements for an Ideal Sensor 770 biological parameters of a measured environment and to
. Challenges in Rational Design of Sensing 771 convert this information into an analytically useful signal.
Materials
In a sensor device, a sensing material is applied onto a
2. Combinatorial and High-Throughput Materials 772 suitable physical transducer to convert a change in a property
Screening
of a sensing material into a suitable physical signal. The
. General Principles 772 obtained signal from a single transducer or an array of
. Opportunities for Sensing Materials 773 transducers is further processed to provide useful information
. Gradient and Discrete Sensing Material 774 about the identity and concentration of species in the sample.
Libraries The energy transduction principles that have been employed
. binatorial Libraries 775 for chemical and biological sensing involve radiant, electrical,
3. anic Sensing Materials 775 mechanical, and thermal types of ,5 Specific sensing
. Catalytic Metals for Field-Effect Devices 775 concepts are further implemented with each energy trans-
. Metal Oxides 777 duction. Sensors based on radiant energy of transduction can
. Conductometric Metal Oxide Sensors 777 employ intensity, wavelength, pola