文档介绍：Psoriasis
Department of Dermatology
The First Affiliated Hospital of Sun Yat-sen University
CHEN Xiao-hong
Definition
Etiology and Pathogenesis
Types and Clinical Features
Histopathology
Diagnosis and Differential Diagnosis
Treatment
Overview of Psoriasis
Definition
Psoriasis is mon, chronic, recurrent, inflammatory disease of the skin characterized by red papules(丘疹) and plaques(斑块) covered with scaling(鳞屑).
Introduction
牛皮癣
Incidence: -3%
M:F ratio: 1:1
Age of onset: 25 - 33 yrs
Season: spring
winter
( Epidemiology. Chapter IV, A Psoriasis. , Kimball AB )
Etiology
factors
20% +ve family history
Early-onset type (16-22 yrs) has a stronger hereditary association than the late-onset type (57-60 yrs).
HLA-Cw6, DR7 antigen with psoriasis
Genes responsible:1q、3q、4q、6p、17q
polygenic inheritance
2. Triggering factors
Infection: bacteria (oci A), virus, yeast
Environment: trauma, surgery, pregnancy,
alcohol consumption, smoking
Psychological: emotional stress, death event, family problem
Drugs: β- blockers, angiotensin-converting enzyme inhibitors(ACEI), antimalarials, lithium
Etiology
Theory
After processing by antigen presentation cell, the antigen is presented to CD4 T-lymphocytes → production of cytokines → stimulate keratinocytes → proliferation and expression of adhesion molecules by endothelial cells → infiltration of leukocytes into the skin lesions
Immunopathogenesis
Types of Psoriasis
Psoriasis vulgaris (寻常型银屑病)
Pustular psoriasis (脓疱型银屑病)
Arthropathic psoriasis (关节型银屑病)
Erythrodermic psoriasis (红皮病型银屑病)
Psoriasis Vulgaris (寻常型银屑病)
Typical lesions(皮疹): circumscribed red papules and plaques covered with thick silvery or white scales