胍基丁胺对大鼠肺动脉张力的调节及受体机制的初步研究.pdf

文档介绍：第三军医大学
硕士学位论文
胍基丁胺对大鼠肺动脉张力的调节及受体机制的初步研究
姓名:项德坤
申请学位级别:硕士
专业:病理生理学
指导教师:高钰琪
20040501
第三军医大学硕士研究生论文
英文缩写一览表
英文缩写英文全称中文全称
ACH acetylcholine 乙酰胆碱
ADC arginine decarboxylase 精氨酸脱羧酶
AGM agmatine 胍基丁胺
α2-AR α2-adrenergic receptor α2-肾上腺素能受体
L-Arg L-arginine 左旋精氨酸
CDS clonidine displacing substance 可乐定置换物质
COX cyclooxygenase 环氧合酶
HPH hypoxic pulmonary hypertension 缺氧性肺动脉高压
IR imidazoline receptor 咪唑啉受体
Gly glybenclamide 优降糖
LV left rentriclar weight 左心室重量
MPAP mean pulmonary artery pressure 肺动脉平均压
L-NAME Nω-nitro-L-hyl ester Nω-硝基-L-精氨酸甲酯
NO nitric oxide 一氧化氮
NOS nitric oxide synthase 一氧化氮合酶
OD optical density 光密度
PASP pulmonary artery systolic pressure 肺动脉收缩压
PBS phosphate buffer saline 磷酸盐缓冲液
PE phenylephrine 苯肾上腺素
RV right ventricular weight 右心室重量
RVDP pulmonary artery diastolic pressure 肺动脉舒张压
SEP interventtricular septum 室间隔
TEA tetraethylammonium 四乙基铵

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第三军医大学硕士研究生论文
Primary study of regulation effects of agmatine on pulmonary
artery tension and its receptor mechanisms in rats

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第三军医大学硕士研究生论文






zed production from L-arginine via nitric oxide synthase (NOS),
distributed widely and has various biological function in mediating vascular tone and vascular smooth cell
proliferation. In vivo, L-arginine does not only transform into NO via nitric oxide synthase, but also
transform to agmatine via arginine decarboxylase, and the latter is also an important metabolic pathway.
The primary studies in the recent years show arginine decarboxylase and related receptor distributed in the
pulmonary vascular endothelial cells and pulmonary vascular smooth muscle cells. In the bovine cultured
2+
pulmonary artery endothelial cells, agmatine act on imidazoline I2R, induce Ca transient response, make
the production of NO increase by three tmes. This appears that agmatine play an important role in the