文档介绍：壳聚糖论文:壳聚糖的改性研究
【中文摘要】本论文首先利用甲氧基聚乙二醇(mPEG)改善壳聚糖的水溶性。将不同分子量的mPEG的羟基羧化后,与壳聚糖分子链上3位羟基发生酯化反应,制备出梳形可分散于水的甲氧基聚乙二醇接枝壳聚糖(CS-g-mPEG)。采用红外光谱(IR)、核磁共振(1H-NMR)对CS-g-mPEG的结构进行了表征,结果表明这种方法可以成功制备CS-g-mPEG。接枝共聚物水溶性实验表明,CS-g-mPEG接枝共聚物的溶解性得到显著提高。为了改善壳聚糖的脂溶性,本论文在壳聚糖上面引入聚乳酸,壳聚糖上的羟基引发丙交酯开环聚合得到壳聚糖-聚乳酸(CS-g-PLA)接枝共聚物。采用红外光谱(IR)和核磁共振(1H-NMR)表征了接枝共聚物的结构。共聚物的脂溶性实验表明,壳聚糖接枝聚乳酸后可以溶解在部分有机溶剂中。另外,本文还利用胺解技术在聚乳酸膜表面引入自由氨基,再利用戊二醛将氨基转化为自由醛基,然后用壳聚糖涂层的方法,制备了壳聚糖表面改性的聚乳酸膜载体。采用红外光谱(IR)对改性聚乳酸膜的结构进行分析表征。结果表明,壳聚糖可以成功固定在聚乳酸膜表面。壳聚糖接枝聚乳酸膜表面后可以改善聚乳酸的生物相容性。
【英文摘要】Firstly, water solubility of the chitosan was improved by methoxy poly(ethylene glycol)(mPEG) in this paper. mPEG with different molecular weights after carboxylated was occurred esterification reaction to the hydroxyl groups at C-3 on the chitosan
backbone, and b-shaped methoxy poly(ethylene glycol) grafted chitosan(CS-g-mPEG) which can be dispersed in water was prepared. The structure of CS-g-mPEG was characterized by infrared spectroscopy (IR) and nuclear ic resonance(’H-NMR), and the results showed that CS-g-mPEG can be essfully prepared by this method. Water-soluble experiment of the graft copolymer showed that the solubility of the CS-g-mPEG graft copolymer was improved (PLA) was introduced to chitosan, and the graft copolymer of chitosan-g-polylactide(CS-g-PLA) was synthesized essfully through ringopening polymerization by the hydrox