文档介绍：心血管病学进展 2009年第 30卷第 3期 Adv Cardiovasc D is, M ay 2009, Vo l. 30, N o. 3 # 413#
肾素-血管紧张素系统阻断剂与心房颤动
张后民综述陈明审校
(重庆医科大学附属第一医院心内科, 重庆 400016)
Blockers of Renin Angiotensin System and A trial Fibrillation
ZHANG H ou-m in, CH EN M ing
(D epartmen t of Card iology, T he F irstA ff ilia ted H osp ital of Chongq ing M ed ical University, Chongq ing 400016, China )
文章编号: 1004-3934( 2009) 03-0413-04 中图分类号: R972; R 541. 7 文献标识码: A
摘要: 心房颤动是临床最常见的心律失常之一, 发病率呈增加趋势。心房电重构和结构重构是心房颤动维持和复发的主要
机制, 肾素-血管紧张素系统在心房重构中起重要作用。肾素-血管紧张素系统阻断剂(血管紧张素转化酶抑制剂和血管紧张素受体
阻断剂)通过抑制心房不应期缩短和抗心房结构重构等作用抑制心房重构并减少心房颤动的发作。肾素-血管紧张素系统阻断剂
影响心房结构和功能, 为心房颤动的防治提供了一种新的选择。
关键词: 心房颤动; 肾素-血管紧张素系统; 心房重构
Abstrac t: A trial fibrillation is one of the m mon arrhy thm iaa. E lectrica l and struc tura l remode ling is the m a jor m echan ism in
the occurrence and m ain tenance o f atria l fibrillation. R en in ang iotensin system ( RA S) play an im portant ro le in a tria l remodeling. Blockers
o f RA S ( ang iotensin-converting enzym e inh ib itors and ang io tensin receptor blockers) inhib it rem ode ling and reduce a tria l fibrillation by in-
h ibiting the atrial refractory period shortening, and an t-i a tria l structural rem ode ling. It provides a new cho ice for the prevention and treatm ent
o f atrial fibrillation.
K ey word s: a tria l fibrillation; ren in ang io tensin sy stem ; atria l remodeling