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. No-Air Techniques Guide
Working on a vacuum manifold:
See LLP chapter for an excellent discussion on working with air-sensitive reagents,
including how to use a two-way manifold.
De-gassing solvents:
The best way to remove water and oxygen from a solvent is to distill it over an appropriate
drying agent (such as sodium). This can sometimes be a lengthy (and dangerous) task. Since we
will only need a small amount of oxygen-free solvent in , it is more efficient to de-gas the
solvent by purging with an inert gas, in this case N2.
1) Place some activated molecular sieves in a hot round-bottomed flask, and purge with
nitrogen until cooled to room temperature. Glass readily adsorbs moisture from the air, so
it is important to thoroughly oven (or flame) dry all glassware. The sieves will act as a
sponge to pick up water dissolved in the solvent.
2) When the flask has coole