Male hypogonadism.ppt

文档介绍：Male hypogonadism
Definition
A decrease in either of the two major functions of the testes:
sperm production
testosterone production
Hypothalamic-Pituitary-Testis Axis
Inhibin B
Testosterone
Testosterone metabolism
Testosterone
60 % - sex hormone binding globulin
38 % - albumin
cortisol binding globulin
2 % - free form
Bioavailable
Testosterone
Testosterone function
Male sexual differentiation
Secondary sex characteristic in puberty and adult
Spermatogenesis
Muscle strength, Muscle volume
Bone density
Erythropoisis
Androgen Deficiency Symptoms
Musculoskeletal
Decreased vigour and physical energy
Diminished muscle strength
Sexuality
Decreased interest in sex
Reduction in frequency of sexual activity
Poor erectile function/arousal
Loss of nocturnal erections
Reduced quality asm
Reduced volume of ejaculate
Androgen Deficiency Symptoms
Mood disorder and cognitive function
Irritability & lethargy
Decreased sense of well-being
Lack of motivation
Low mental energy
Difficulty with short-term memory
Depression
Low self-esteem
Insomnia
Nervousness
Androgen Deficiency Symptoms
Vasomotor and nervous
Hot flushes
Sweating