文档介绍：Hemorrhagic Fever Virus
出血热病毒
Department of Microbiology, HMU
第34章
Haemorrhagic Fever with Renal Syndrome (HFRS: later renamed hantavirus disease, HVD) first recognized in Heilongjiang, China in the 1930s, and came to the attention of the West during the Korean war when over 3000 UN troops were afflicted
It transpired that the disease was not new and had been described by the Chinese 1000 years earlier
In 1974, the causative was isolated from the Korean Stripped field mice and was called Hantaan virus
In 1995, a new disease entity called hantavirus pulmonary syndrome was described in the “four corners” region of the .
病毒体 Virion
Forms a separate genus in the Bunyavirus family 布尼雅病毒科
Unlike other bunyaviridae, its transmission does not involve an arthropod vector
Enveloped -ssRNA virus
Virions 98nm in diameter with a characteristic square grid-like structure.
Genome consists of three RNA segments: L, M, and S.
基于中和试验的血清型Subtypes of Hantaviruses Based NT
黑线姬鼠型
褐家鼠型
欧洲棕背鼠型
草原田鼠型
巴尔干姬鼠型
小家鼠型
根据抗原和基因结构分型(10型)
Hantaan(汉滩型)
Porrogia and related viruses - This group is found in China, Eastern USSR, and some parts of S. Europe. It is responsible for the severe classical type of hantavirus disease. It is carried by stripped field mice. (Apodemus agrarius)
Seoul type(汉城型)
associated with moderate hantavirus disease. It is carried by rats and have a worldwide distribution. It has been identified in China, Japan, Western USSR, USA and .
Puumala type
mainly found in Scandinavian countries, France, UK and the Western USSR. It is carried by bank voles (Clethrionomys glareolus) and causes mild hantavirus disease (nephropathia epidemica).
Sin Nombre(辛诺柏型)
found in many parts of the US, Canada and Mexico. Carried by the Deer Mouse (Peromyscus maniculatus) and causes hantavirus pulmonary syndrome.
流行病毒学 Epidemiology
Natural host: Rodent Apodemus agrarius (Stripped field mice, 黑线姬鼠)
传染源:黑线姬鼠、褐家鼠、大林姬鼠
Viral es from rodent urine, stool, salivary secretion
Seasona