文档介绍：Thrombosis
Thrombus
Thrombi
Section B
ANTITHROMBOTIC PROPERTIES
Inhibition of platelet aggregation:
PGI2, NO, ADPase
Anticoagulant -binding and inhibition of
thrombin: Antithrombin III acceleration
by heparin-like molecules, thrombomodulin
activation of protein C/S, 2-macroglobulin.
Fibrinlysis: Tissue plasminogen activator (tPA)
PROTHROMBOTIC PROPERTIES
Simulation of platelet aggregation
(adhesion): von Willebrand factor,
platelet-activating factor.
Procoagulation factors: Tissue factor,
binding factors IXa and Xa, Factor V.
Inhibition of fibrinolysis: t-PA inhibitor.
Fig 5-5
Fig 5-6
THREE INFLUENCES OF THROMBOSIS
Endothelial injury (most important).
Alone can induce thrombosis.
Alterations in normal flow.
Hypercoagulability.
When the last two are both present,
endothelial injury is not requisite.
Fig 5-8
Endothelial injury
Ulcerative atherosclerosis
Transmural myocardial infarction
Vasculitis
Trauma
Radiation
Bacterial toxins
Alterations in normal blood flow
Platelets activated by contact with
endothelium.
Slowed flow retards dilution of activated
clotting factors and hepatic clearance.
Stasis or turbulence retards the inflow of
inhibitors.
Turbulence may induce endothelial injury