文档介绍：四川大学
华西基础医学与法医学院
药理学教学大纲
药理学-Ⅰ
药理学教研室
2006 年 5 月
《药理学》教学大纲
一、课程基本信息
课程中文名称药理学-Ⅰ课程英文名称 pharmacology-Ⅰ
课程号 50128050 课程类别基础课
学时 85 学时学分 5 学分
二、教学目的及要求:
Pharmacology is one of the important basic medical sciences. It is a interdisciplinary course
which has close relationship with many other medical and disciplines, such as physiology,
biochemistry, immunology, pathology, anatomy, histology, and clinical medicines as well, it is a
bridge between the basic medical sciences and clinical medicines. It is a study of the
pharmcodyanamics and ics, the course are grouped into five parts, these include
general principle, autonomic agents, renal and cardiovascular drugs, central nervous systems agents,
and chemotherapeutic drugs. This course is intended to introduce the basic knowledge about the
structure of the drug, the mechanism of drug actions and the therapeutic usefulness of the drug in the
treatment of diseases are stressed.
三、教学内容:
Chapter 1
General Pharmacologic principles iutroduction
1. Drugs: concept
2. Pharmacology: major content of pharmacology: Pharmacodynamics and ics. The
responsibility of pharmaclogy.
3. History of pharmacology.
4. New drug development and research.
Chapter 2
Effects of drugs on the body – Pharmacodynamics
1. Drug’s action and pharmacological effect.
2. The basic display of Drug action.
3. Specificity and selectivity.
4. Treatment action and adverse reaction: (Side reaction, toxic reaction, residual effect, withdrawal
reaction, allergic reaction and idiosyncrasy).
5. Drug’s dose – effect relationship: Dose–effect curve, efficacy, Potency, ED50 , LD50 ; Therapeutic
index and Margin of safety.
Drug’s mechanism: concept of receptor, affinity and intrinsic activity, agonist, antagonist and
partial agonist, receptor dynamics. The concept and significance of PD2, PA2 . Receptor classification
and the second mes