文档介绍：摘 要目的:,从活体细胞代谢的角度对老年人静止性脑梗死磁共振T2加权像上赫信号的影像学异常瘸灶的严重程度进行研究。
2。对静止拣脑梗死鳇危险毽素进行耱关关系獗究。方法:研究对象84例,男68例,女16例,± 岁(60一92岁)。研究对缘分为2组:侧脑室体部层面组:35例,波谱分析取侧脑室体部层蔚,分级采用Fasekas量表的PVH分级法。基底节层甏缀:49例,波谱分辑取鍪底节屡嚣,分级采麓Fasekas 量表的SDWMH分级法。为了鳃赢血压、糖尿痫、血脂异常与分级的关系,各组苒分为高血压豫组、糖尿病溉组、皿脂异常亚组。本研究将 SDWMH及PVH分级为0级的作为各研究组的对照组。
所有研究对象送行磁共振检查,包括磁若振乎按(零l翱权鞠T2 加权)、FLAIR成像、DWI、MRS分析,计算感兴趣区NAA,Cr和Cho 的相对信号强度。所有研究对缘MRS感兴趣区均未发现乳酸,说明研究对象脑内无急性梗死病灶。对静止性脑梗死的危险因素(高血压、糖尿瘸、血髓异鬻)进行相关关系研究。结果: 水平的关系,经统计学检验,p<,有显著统计学意义,两者之间等级相关。
2,基底节蔗面缝痰覆下深部自矮高信号S努鼷珏分级与两铡
NAA/Cr水平的关系,经统计学检验,p>0。05,无统计学意义,髑者
毒
之闻等级不襁关。
(P<)。糖尿病与脑室阁围高信号PVH分级的关系经趋势卡方藏验存在统计学差薯(P<o。0i),与皮覆下深都蛊质高信号 SD骣羧分级存在差舞懿趋势,健经统计学检验P>O;05。
4。血脂异常与静止性脑梗死之间不存在统计学上的麓异
(P>0,05)。
结谂;本婿究剽用3嚣磁共振液谱分橱方法觚缀稔代谢静熬度对静止牲艟梗瑟的代落变仡进行谭售,发瑗铡夔室体部层甏麓NAA/Cr下降与Fasekas魑表的脑室周围高俄号PVH分级相关,说昵该指标是腻的供血不足引起的低灌注和小动脉硬化的另一生化指标。对静止性脑梗死患者‘}{滋共振波谱分褥静感菇趣送建议选择铡腻室体部层面。危险霞素赛巍器、糖暴病与静止性脑梗聪关系密切。
关键词:1H磁共搬波谱分析(,W-MRS)静止性脑梗歹E(SCI) 脑寓周围高信号(PVH) 皮质下深部白质商信号(SDWMH) NAA/Cr
Measurement Of Silent Cerebral Infarction With Proton
ic Resonance Spectroscopy(1 )And
Evaluation Of Risk Factors For
Silent Cerebral Infarction
Abstracts
objects:To investigate the change in cell metabolism involved in silent cerebral infarction,we measured the brain metabelites in vivo 耐馈1 proton ic resonance spectroscopy(1H—MRS) correlated to the brain leisions detected by T2一weighted
spin—echo(SE)ic resonance(MR) factors for silent cerebral infarction were also evaluated.
Methods:We examined 84 elderly aged ±(ranged from 60—92). All subjects were examined旗凌MRI(T1W and T2W),FLAIR, DWI and MRS。Amount of NAA,Cr and Che of interested area were calculated according to the signal intensity signal of lactic acid was detected in
interested area in all subjects。
Proton ic resonance spectroscopy was examined at the slice of the bedy of lamral ventricle in 35 subjects and graded according