文档介绍：奥司他韦与替代疗法抗H1N1感染效果的Meta分析
[摘要] 目的研究奥司他韦与非化学合成药物替代疗法抗H1N1感染的效果及安全性。方法检索在Medline、Embase、KI全文数据库以及万方中文期刊全文数据库2014年1月1日之前公开发表的有关流感治疗的文献。采用Cochrane协作网提供的Review Manager 。采用加权平均数作为系统评价的指标并计算其95%可信区间。结果 7篇随机对照临床研究最终纳入本次分析,其中5篇为连花清瘟胶囊与奥司他韦的比较,2篇为银翘散加减方与奥司他韦的比较。系统评价的结果显示,在病毒核酸阴转方面,银翘散组方加减与奥司他韦[WMD = -,95%CI(-,),P = ]以及连花清瘟胶囊与奥司他韦[WMD = -,95%CI(-,),P = ]的效果相似;在退热时间方面,银翘散组方加减与奥司他韦[WMD = ,95%CI(-,),P = ]效果相似,而连花清瘟胶囊要优于奥司他韦[WMD = -,95%CI(-,-),P = ];在咳嗽缓解方面,连花清瘟胶囊的效果优于奥司他韦且两者差异有高度统计学意义[WMD = -,95%CI(-,-),P < ]。结论中药替代疗法在抗流感病毒感染方面有积极作用。
[关键词] H1N1;感染;替代或补充医学
[中图分类号] [文献标识码] A [文章编号] 1673-7210(2014)11(a)-0052-05
Meta-analysis of efficacy of Oseltamivir and substitution therapy for anti- H1N1 infection
ZHANG Ruixin1 LIU Weiwei2
Division, 302 Hospital of PLA, Beijing 100039, China; Teaching and Research Section, Graduate School, Academy of Military Medical Sciences, Beijing 100850, China
[Abstract] Objective To study the efficacy and security of Oseltamivir and substitution therapy for anti- H1N1 infection. Methods Medline, Embase, CBMdisk, Chinese National Knowledge Infrastructure (CNKI) and Wanfang Database were searched for the literature about the treatment of influenza before January 1, 2014. Meta-analysis was performed using the software of Review