金刚藤提取部位和酚性成分的抗HIV-1活性研究.doc

文档介绍：Anti-HIV-1activitiesofextractsandphenolicsfromSmilaxchinaL.#510152025303540WANGWeixin,QIANJingyi,WANGXiaojing,JIAAiqun**(SchoolofEnvironmentalandBiologicalEngineering,NanjingUniversityofScienceandTechnology,Nanjing210014)Abstract:Fourextracts(EtOH,CHCl3,EtOAc,andBuOH)andfivephenolics(dihydrokaempferol(1),resveratrol(2),kaempferol-7-O-β-D-glucoside(3),dihydrokaempferol-3-O-α-L-rhamnoside(4),oxyresveratrol(5))-HIV-,butsomeshowedpotentialanti-HIV-1activities,thatis,pound2showedhigheranti-HIV--HIV-1activitiesataconcentrationhigherthan4μg/,thestructure-:SmilaxchinaL.;phenolics;TZMB-Lcells;anti-HIV-1;-retroviraltreatment(HAART)indeedhaveexpandedpatientlife-timeandimprovelifequalities,butthesechemosyntheticdrugscannoteradicatethepersistentlyorlatentlyinfectedviruses,andeasilyinducedrug-resistance;thestrongside-