文档介绍：中国寄生虫学与寄生虫病杂志年月第卷第期
2012 8 30 4 窑 317 窑
文章编号综述
院1000鄄7423渊2012冤鄄04鄄0317鄄04 揖铱
蓝氏贾第鞭毛虫表面抗原变异机制研究进展
冯宪敏*袁王月华袁鞠晓红
揖提要铱蓝氏贾第鞭毛虫 Giardialamblia 简称贾第虫是引起腹泻的最常见的肠道寄生原虫之一同大多数肠道
渊, 冤遥
寄生的病原体一样表面抗原变异是虫体逃避宿主免疫攻击的重要机制从而
袁渊variant鄄specificsurfaceproteins,VSPs冤袁
导致疾病慢性化和或重复感染的发生本文将从基因水平的调控转录和转录后调控表达修饰调节和的加
/ 遥尧尧 VSPs VSPs
工处理与转运等个方面对贾第虫表面抗原变异机制的研究进展进行综述
尧 4 遥
揖关键词铱蓝氏贾第鞭毛虫;变异特异性表面蛋白;抗原变异;后转录基因沉默机制
中图分类号文献标识码
院 院 A
ResearchProgressontheMechanismsofAntigenic
Variationin Giardialamblia
*
FengXian鄄min 袁 WangYue鄄hua袁 JuXiao鄄hong
DepartmentofPathogenBiology,JilinMedicalCollege,Jilin 132013,China
渊冤
揖Abstract铱 Giardialamblia
Theintestinalprotozoanparasite moncausesofdiarrhoeaand
undergoesantigenicvariation. anisms, antigenicvariationisoftendescribedasamechanismto
evadethehostimmunesystem,resultinginchronicand/,significantadvances
intheknowledgeoftheantigenswitchingprocesshavebeenachieved. Herewereviewtheprincipalknowledgeonthe
mechanismsthatregulatethisprocess, anization,post鄄tanscriptionalgenesilencing, expressional
modifications,andprocessingandturnoverofVSPs.
揖Keywords铱 Giardialamblia;Variant鄄specificsurfaceprotein;Antigenicvariation;Post鄄tanscriptionalgene
silencing PTGS)
渊
SupportedbytheScienceandTechnologyProgramofJilinEducationDevelopment 渊