文档介绍：CarbogenGas–ChallengeBOLDMRImaginginaRatModelofDiethylnitrosamine-inducedLiverFibrosis1NingJin,MS,JieDeng,PhD,TamunaChadashvili,PhD,YueZhang,BS,YangGuo,MD,ZhuoliZhang,MD,Guang-YuYang,MD,PhD,,,PhD+AuthorAffiliations1FromtheDepartmentsofRadiology(.,.,.,.,.,.,.,.),BiomedicalEngineering(.,.,.,.),andPathology(.),(.,.),NorthwesternUniversity,737NMichiganAve,Suite1600,Chicago,IL60611;DepartmentofMedicalImaging,Children’sMemorialHospital,Chicago,Ill(.);andDepartmentofBioengineering,UniversityofIllinoisatChicago,Chicago,Ill(.)..(e-mail:a-******@).Authorcontributions:Guarantorsofintegrityofentirestudy,.,.;studyconcepts/studydesignordataacquisitionordataanalysis/interpretation,allauthors;manuscriptdraftingormanuscriptrevisionforimportantintellectualcontent,allauthors;manuscriptfinalversionapproval,allauthors;literatureresearch,.,.,.,.,.,.,.;experimentalstudies,allauthors;statisticalanalysis,.,.,.,.,.;andmanuscriptediting,.,.,.,.,.,.,. NextSectionAbstractPurpose:Toinvestigatetherelationshipbetweengas-challengebloodoxygenlevel–dependent(BOLD)icresonance(MR)imagingmeasurementsandhepaticdiseaseprogressioninaratmodelofdiethylnitrosamine(DEN)-:%DENsolutionperkilogramofbodyweightfor3–11weeks,(非物质性的纤维化);eightrats,substantialfibrosis;and15rats,cirrhosis(肝硬化).-gradient-echoMRimageswereacquiredintheratsatsteady-(麻醉第二期)*(ΔR2*)duringthegaschallengeandtheratioofnumberofactivatedvoxels(三位像素)tototalnumberofvoxelsin