加巴喷丁与普瑞巴林对比.pptx

文档介绍：加巴喷丁与普瑞巴林区隔辉瑞医学部PfizerConfidential–InternalUseOnlyDraft–NotforDistribution,DoNotDetail加巴喷丁和普瑞巴林的化学结构差异2合成的支链氨基酸抑制性神经递质g-氨基丁酸(GABA)的结构衍生物PfizerConfidential–InternalUseOnlyDraft–NotforDistribution,DoNotDetailBockbraderHN,etal..2010;49:661–,并随之抑制兴奋性神经递质的释放1普瑞巴林对Ca2+通道a2d亚基的亲和力比加巴喷丁高(40nmol/Lvs32nmol/L)2,PfizerConfidential–InternalUseOnlyDraft–NotforDistribution,;142:13–;29:203-(h)3-4≤1(吸收快)线性/非线性非线性线性肠道吸收部位局限广泛生物利用度绝对生物利用度(%)60-30(900-3600mg/d)≥90(75-900mg/d)(3倍)PfizerConfidential–InternalUseOnlyDraft–NotforDistribution,DoNotDetailBockbraderHN,etal..2010;49:661––InternalUseOnlyDraft–NotforDistribution,DoNotDetailBockbraderHN,e