文档介绍：首发精神分裂症患者血清GFAP与认知功能的研究
李国华* 李继荣◎吴秋霞* 熊鹏* 曾勇* 徐飞* 卢瑾* 姜林伶*
☆ 云南省社会发展科技计划项目(编号:2011CA018)
云南省应用基础研究计划项目(编号:2011FB172)
* 昆明医科大学第一附属医院精神科(昆明 650031)
◎ 湖北省黄石市精神病院(黄石 435004)
※通讯作者(E-mail:zhangsl900@)
【摘要】目的研究首发精神分裂症患者血清中胶质纤维酸性蛋白(Glial Fibrillary Acidic Protein,GFAP)水平的变化与认知功能障碍之间的关系。方法用酶联免疫吸附技术(Enzyme-linked Immunoadsordent Assay,ELISA)测定48例精神分裂症患者和42例正常对照者血清GFAP的浓度,并用威斯康星卡片分类测验(Wisconsin Cord Sorting Test, WCST)检测首发精神分裂症患者和正常人的认知功能。比较首发精神分裂症患者和对照组血清GFAP浓度,同时探讨GFAP浓度的变化与认知功能的关系。结果(1)首发精神分裂症患者血清浓度高于对照组(P<);(2)患者组WCST成绩低于对照组(P<),表明首发精神分裂症患者认知功能及执行能力比正常人差;(3)相关分析表明WCST 中错误应答数、持续性错误数与患者血清GFAP浓度呈正相关,完成分类个数与患者血清GFAP浓度呈负相关(P<)。结论首发精神分裂症患者存在认知功能障碍和神经胶质细胞损害,且代表神经胶质细胞损害的血清GFAP浓度与认知功能障碍程度呈正相关。
【关键词】精神分裂症 GFAP 认知功能障碍
【中图分类号】 【文献标识码】 A
Research on serum GFAP levels and cognitive function in first episode schizophrenia.
LI Guohua. Department of Psychiatry,The First Affiliated Hospital of Kunming Medical University,Kunming 650031,China.
【Abstract】 Objective To study the relevance between serum glial fibrillary acidic protein levels and cognitive dysfunction in first episode schizophrenic patients. Methods Serum GFAP concentrations were measured in 48 patients with schizophrenia and 42 normal controls with enzyme linked immunoadsordent techniques, cognitive functions of schizophrenic group and normal group were assessed by Wisconsin cord sorting test. parison was ma