文档介绍：队列研究CohortStudy队列研究CohortstudyIncidencestudiesLongitudinalstudiesFollow-upstudiesProspectivestudies发病率研究纵向研究随访研究前瞻性研究OutlineExampleDesignandimplementMeasuresofRiskDatasortandanalysisBiasandControlAdvantage,disadvantage概述实例研究设计与实施资料的整理与分析偏倚及控制优缺点队列研究Cohortstudy队列研究简史定义与目的原理与类型HistoryofcohortstudyDefinitionandPurposePrincipleandTypes历史History起源OriginsGraunt(17thcentury)usedcross-sectionalmortalitydatatoreconstructlifehistoryusinglife-tablemethodsGraunt(17世纪)用横断面死亡资料,用寿命表方法构建生命史Farr(19thcentury)advancedtheuseoflife-tablemethodsaanindicatorofpopulationhealthFarr(19世纪)将寿命表方法发展为人群健康的指标Insuranceindustrystudy1870–1899保险业研究1870–1899Tuberculosis(20thcentury)结核(20世纪)WHFrostperformedthefirstretrospectivecohortstudyinacohortof132homeswithtuberculosisWHFrost在有结核的132个家庭的队列开展第一个回顾性队列研究Usedperson-yearstoestimateattackrates用人年来估计罹患率历史HistoryWHFrostinitiatedprospectivecohortstudyoftuberculosisinWilliamsoncounty,TennesseeWHFrost在德州启动有关结核的前瞻性队列研究历史HistoryFraminghamstudyofcardiovasculardisease,1948Japaneseatomicbombsurvivors,1946Britishphysicianstudy,1950sColoradoPlateauuraniumminers,1950sAniline-upationalcohort,1954Asbestosexposureandlungcancermortality1965RetrospectivecohortstudiesProspectivecohortstudiesNursesHealthstudy,1976topresentBritishphysicianstudyMulti-centerAIDSCohortStudyMACS,1984–1999CurrentStudiesAnepidemiologicdesigninwhichtheincidenceofadisease(orcondition)paredamongexposedandunexposedindividuals是比较暴露与非暴力人群发病率的一种流行病学设计定义What’thecohortstudy