文档介绍：The DNA Damage Response: Implications
on Cancer Formation and Treatment
Kum Kum Khanna · Yosef Shiloh
Editors
The DNA Damage Response:
Implications on Cancer
Formation and Treatment
123
Editors
Dr. Kum Kum Khanna Dr. Yosef Shiloh
Queensland Institute of Tel Aviv University
Medical Research Sackler School of Medicine
Signal Transduction Dept. Human Molecular ics &
Biochemistry
Laboratory 69978 Tel Aviv
300 Herston Road Ramat Aviv
Herston QLD 4006 Israel
Australia ******@
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ISBN 978-90-481-2560-9 e-ISBN 978-90-481-2561-6
DOI -90-481-2561-6
Springer Dordrecht Heidelberg London New York
Library of Congress Control Number: 2009927008
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Preface
The field of cellular responses to DNA damage has attained widespread recognition
and interest in recent mensurate with its fundamental role in the main-
tenance of genomic stability. These responses, which are essential to preventing
cellular death or malignant transformation, anized into a sophisticated sys-
tem designated the “DNA damage response”. This system operates in all living
organisms to maintain genomic stability in the face of constant attacks on the
DNA from a variety of endogenous by-products of normal metabolism, as well as
exogenous agents such as radiation and toxic chemicals in the environment. The
response repairs DNA damage via an intricate cellular signal work
that coordinates with various processes such as regu