文档介绍：758 J Clini Hepatol, July 2011, ,
综述
肝脏自然杀伤细胞在慢性肝病中的作用
程琦,施光峰
(复旦大学附属华山医院感染科,上海 200040)
摘要: 肝脏自然杀伤细胞(NK)是一种与外周血NK细胞不同的肝脏免疫细胞。近年来研究表明肝脏NK细胞在各种慢性
肝脏疾病中起重要作用。包括对抑制病毒感染和肿瘤细胞生长,对抗肝纤维化均有益处,但同时其又刺激肝损伤和抑制肝再生
(肝细胞增殖)。本文就肝脏NK细胞的特征、功能以及在各种常见慢性肝病中作用进展作一综述。
关键词: 杀伤细胞,天然;肝细胞;肝疾病
中图分类号: R575 文献标识码: A 文章编号: 1001-5256(2011)07-0758-04
Role of liver NK cells in chronic liver diseases
CHENG Qi, SHI Guang-feng. (Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200040, China)
Abstract: Liver natural killer cells (NK) cells are one type of hepatic immune cells derived from peripheral blood NK cells. Recent
studies show that liver NK cells play an important role in various chronic liver diseases, including inhibition of viral infection and tumor
cell growth and anti fibrosis. On the other hand, they also cause liver injury and inhibit liver regeneration. In this paper, the features and
functions of liver NK cells and the recent progress of the role of liver NK cells in chronic liver disease are reviewed.
Key words: killer cells, natural; hepatocytes; liver diseases
1976年,Wisse等首次在大鼠肝窦状细胞中发现一型和功能。这些细胞被称作自然杀伤树突细胞(NKDC
种新型细胞,称为“pit细胞”,以细胞浆内具有颗粒细胞或者IKDC细胞)(C57BL/6小鼠肝脏NK表面标记
为特征,现在已知是肝脏自然杀伤细胞(natural killer CD11cintB220+CD49+MHC Ⅱ+ )[1] 。
cell,NK)。与外周血NK细胞相比,肝脏NK细胞表现外周血和肝脏NK细胞骨髓源的外周血NK细胞迁
出不同的免疫表型、形态和功能特征。近来一些研究移到肝脏,进而分化成特异性肝脏NK细