文档介绍：Chinese-German Journal of Clinical Oncology February 2011, Vol. 10, No. 2, P85–P87
DOI -011-0753-3
Gemcitabine plus carboplatin used as induction
regimen for elderly patients with locally advanced
unresectable non-small cell lung cancer
Zhihua Sun, Hongmin Zheng, Linyun Zhang
Department of Oncology, Xiangfan Central Hospital, Xiangfan 441021, China
Received: 1 December 2010 / Revised: 20 December 2010 / Accepted: 16 January 2011
© Huazhong University of Science and Technology and Springer-Verlag Berlin Heidelberg 2011
Abstract Objective: The purpose of this study was to evaluate the efficacy and safety of gemcitabine (GEM) and carbo-
platin (CBP) used as induction regimen in the treatment of elderly patients with locally advanced unresectable non-small cell
lung cancer (NSCLC). Methods: Seventy-eight cases of elderly patients have been cytologically and pathologically confirmed
with locally advanced unresectable NSCLC, the age of the patients ranged from 65 to 75 years. The patients were treated with
bined regimen of gemcitabine and cisplatin. GEM 1000 mg/m2 intravenously injected by drip on the 1st, 8th day and
the dosage of CBP was AUC 4 that was used on the 1st day, 21 days apart to each cycle, most patients received 2 cycles.
Treatment response was evaluated according to the criteria of RECIST (Response Evaluation Crite