文档介绍：温阳益心法对动脉粥样硬化大鼠血清C反应蛋白和白细胞介素-6水平的影响
作者:唐丹丽,曹洪欣,张华敏
【摘要】目的观察温阳益心法对动脉粥样硬化(AS)大鼠炎性细胞因子水平的影响,探讨其防治AS的机制。方法将72只雄性Wistar大白鼠随机分为6组:空白组、模型组、西药组及温阳益心复方低、中、高剂量组。采用高脂饲料喂饲及腹腔注射维生素D方法建立大鼠AS模型,制模成功后给予相应的药物6周,分别测定各组C反应蛋白(CRP)和白细胞介素-6(IL-6)的浓度。结果与空白组比较,模型组CRP和IL-6均明显升高(P<),温阳益心复方高剂量组血清CRP和IL-6水平均明显低于模型组(P<),与西药组比较差异无显著性。结论温阳益心法可能通过抗炎机制,发挥抑制AS的作用。
【关键词】温阳益心法;动脉粥样硬化;C反应蛋白;白细胞介素-6;大鼠
Abstract:Objective To discuss the precautionary mechanism of atherosclerosis by observing the effect of the treatment of warming yang and supplementing heart qi on inflammaory factors levels in atherosclerosis rat serum. Method 72 rats were divided into 6 groups randomly:normal group, model group, simvastatin group and three groups with different dose of Chinese herbal medicine. An animal model of AS was established by injecting vitamine E in high fat-fed rats. When the model was established essfully, corresponding medicine were supplied for 6 weeks and then the contents of CRP and IL-6 in rat serum were measured. Results The levels of CRP and IL-6 were significantly higher in model groups than the normal group (P<). The expressional level was similiar in the rats of high dose of warming yang and supplementing heart pound treating group and the simvastatin group, but it was expressed less obviously than the model group (P<). Conclusion The treatment of warming yang and supplementi