文档介绍：原发性痛风家系男性与女性痛风病人的比较
【摘要】目的探讨原发性痛风家系不同性别病人的临床特点。方法对比分析19个原发性痛风家系中40例男性病人和19例女性病人的临床特征及生化检测指标。结果女性36~45岁年龄段痛风构成比明显低于男性(χ2=,P<)。并发肥胖、高血压、糖代谢紊乱、脂代谢紊乱的概率女性病人与男性病人相比差异无统计学意义。女性痛风病人腰臀比、TG明显低于男性痛风病人(t=、,P<), BUN明显高于男性痛风病人(t=,P<)。结论对于有痛风家族史的病人(无论男性还是女性),应定期查体,以便早期发现和及时治疗痛风。
【关键词】原发性痛风高尿酸血症家系
[ABSTRACT]ObjectiveTo study the clinical characteristics of male and female gout patients from gout family. Methods
pare and analyze the clinical characteristics and laboratory data of 40 male and 19 female patients from 19 gout constituent ratio of female patients at the age of 36-45 years was pared with the male patients (χ2=,P<). The levels of TG and WHR in the female patients were significantly lower than those in the male (t=,;P<). BUN level in the female patients was significantly higher than in the male (t=, P<).ConclusionRegular medical examination is mended to family members with a famili
al history of gout in order to get early diagnosis and treatment for new patients.
[KEY WORDS]primary gout; pedigree hyperuricemia; family
在排除其他疾病的基础上,由于先天性嘌呤代谢障碍和(或)尿酸排泄减少所致的痛风称为原发性痛风。该病多见于老年男性,女性发病率较低,男女之比约20∶1。迄今,已明确该病为多基因遗传性疾病,有明显遗传背景。但有关家系痛风病人中男性和女性病人临床特征不同之处,目前尚无定论。本文以19个痛风家系中40例男性和19 例女性病人为研究对象分析如下。
1 材料和方法
一般资料
所有痛风病人均来自青岛大学医学院附属医院内分泌科门诊及2004年6~10月山东沿海地区痛风流行病学调查资料。除先证者外,直系亲属中至少还有1人明