文档介绍：鸣谢:沈剑波、王海林、孙俊龙、张玉鑫、汤晨雪、吴慧、郑雅、戴璐、方淼、孔亚男、张舒文、徐阳、蔡水灵、刘珊等同学的无私奉献整理:临床小胖子一、pleaseillusratehowtodevelopanewdrug(p4)Mostnewdrugsordrugproductsarediscoveredordevelopedthroughthefollowingapproaches:identificationorelucidationofanewdrugtarget;Rationaldesignofanewmoleculebasedonanunderstandingofbiologicmechanismsanddrugreceptorstructure;Screeningforbiologicactivityoflargenumbersofnaturalproducts,banksofpreviouslydiscoveredchemicalentities,orlargelibrariesofpeptides,nucleicacids,anicmolecules;Chemicalmodificationofaknownactivemolecule,resultinginame-(1)and(2)areoftencarriedoutinacademicresearchlaboratories,butthecostsofsteps(3)and(4)、Pleasetellthemeaningofloadingdoseandmaintenancedose?(p17):,,therateof